2016), whose presence in certain populations of Latin America ( Cervantes et al. It is thus, not surprising that the first HPV vaccines were directed toward these genotypes ( MuР“В±oz et al. Persistent infection with high-risk types 16 and 18 contributes to 20% and 50% of cervical cancers, respectively ( Skeate et al. Approximately 90% of HPV infections resolve spontaneously through the immune system. Persistent infection with this virus is associated with squamous carcinoma of the cervix, oropharynx, anus, genitalia (vulva, vagina and penis), head, and neck. Several risk factors for HPV infection have been identified, and include genetic predisposition, immune status, co-infection with other sexually transmitted diseases, and smoking. The vaccine against the human papillomavirus (HPV) - HPV infection is the most common sexually transmitted viral infection. We also compare the different approaches on HPV vaccine policies regarding its adverse reactions in countries like Japan and Colombia, vs. In this article we bring the attention on certain adverse effects of the vaccine against HPV that have not been well studied as they are not well defined. Side-effects, however, should be closely monitored and reported without any bias, to ensure that the benefits of vaccines outweigh the risks of adverse reactions. There is no doubt of the benefit of vaccines in the reduction of the incidence of infectious diseases, and in the case of HPV, the prevention of persistent infection that would lead to cervical cancer. The immunogenetic background of the host, and HPV antigen recognition, are important in natural HPV infection, and should be taken into account in the understanding of adverse autoimmune reactions by the HPV vaccine in certain groups. Despite being more than ten years since its introduction, global acceptance to the human papillomavirus (HPV) vaccine is still low.

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